IPMG Research
IPMG is excited to introduce our new research department.
We are looking forward to offering innovative and novel treatments in the studies we are offering at our Loma Linda location. Our research team is waiting to hear from you.

Spravato Treatment
Esketamine Nasal Spray

What is Spravato Treatment?

FDA-approved prescription nasal spray
SPRAVATO® (esketamine nasal spray) is an FDA-approved prescription nasal spray, used along with an antidepressant taken orally to treat:
- Adults with treatment-resistant depression (TRD)
- Depressive symptoms in adults with major depressive disorder (MDD) with suicidal thoughts or actions
Esketamine is in a class of medications called NMDA receptor antagonists. It works by changing some naturally occurring chemicals in the brain, though the exact mechanism by which it exerts its antidepressant effect is unknown.
Spravato contains esketamine hydrochloride, which has a chemical formula that is a mirror image of ketamine. It is designated as a Schedule III controlled substance under the Controlled Substances Act.
Because of potential risk of serious side-effects, Spravato can only be administered by the Risk Evaluation and Mitigation Strategy (REMS) certified treatment center.
FAQ
If you are seeking treatment for any of the above indications and you are not at the risk of having serious side effects with Spravato, it may be a good treatment option for you.
Please schedule an appointment with one of our providers to determine whether Spravato would be a good treatment option for you.
If you take a nasal corticosteroid or nasal decongestant medicine, take these medicines at least one hour before taking Spravato. You should also request a family member or friend to drive you to and back from each appointment.
After each administration, you will be monitored in the office for about 2 hours. If the provider decides that it’s safe for you to leave office, then you should have a family member or a friend drive you back home from office.
Depending on your progress, if further maintenance treatment is required, your healthcare provider will discuss treatment options with you.
Each Spravato administration appointment typically lasts about 2 hours.
Spravato contains esketamine hydrochloride, which has a chemical formula that is a mirror image of ketamine. It is designated as a Schedule III controlled substance under the Controlled Substances Act and therefore it may carry serious risk of abuse and misuse. Some patients may experience one or more of the following side effects with Spravato:
- Sedation or sleepiness
- Dizziness – fainting or spinning sensation
- Dissociation – feeling disconnected from yourself, your thoughts, feelings, space and time (dissociation)
- Increase in anxiety
- Physical and psychological dependence
- Nausea and vomiting
- Increased blood pressure
- Feeling drunk
- Decreased sensitivity (numbness)
- Lack of energy
- Increased suicidal thoughts and actions
- Difficulty in urination
Spravato is not recommended for patients with the history of treatment for ballooning or bulging blood vessels (aneurysms), bleeding due to brain injury, and hypersensitivity to esketamine or ketamine or ingredients in esketamine spray.
BOOK APPOINTMENT FOR SPRAVATO TREATMENT
This appointment booking page is only for Spravato Treatment. Do not use this page to book for regular appointment.