SPRAVATO® (esketamine nasal spray) is an FDA-approved prescription nasal spray, used along with an antidepressant taken by mouth to treat:
- Adults with treatment-resistant depression (TRD)
- Depressive symptoms in adults with major depressive disorder (MDD) with suicidal thoughts or actions
Esketamine is in a class of medications called NMDA receptor antagonists. It works by changing some naturally occurring chemicals in the brain, though exact mechanism by which it exerts its antidepressant effect is unknown.
Spravato contains esketamine hydrochloride, which has a chemical formula that is a mirror image of ketamine. It is designated as a Schedule III controlled substance under the Controlled Substances Act.
Because of potential risk of serious side-effects, Spravato can only be administered by the Risk Evaluation and Mitigation Strategy (REMS) certified treatment center.